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Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0513-4870.2003.08.001
- Key Word:
- 阿司匹林;脑缺血-再灌注损伤;前列环素I2/血栓素A2;丙二醛;5′-三磷酸腺苷
Abstract： 目的观察阿司匹林对大鼠脑缺血-再灌损伤的保护作用.方法线栓法制作局部脑缺血2 h、再灌24 h模型,观察阿司匹林6和60 mg*kg-1对脑损伤面积、水肿程度及血前列环素I2(PGI2)/血栓素A2(TXA2)、一氧化氮(NO)、内皮素(ET)及脑组织丙二醛(MDA)、超氧化物歧化酶(SOD)和ATP含量的影响.结果两个剂量阿司匹林均明显缩小再灌引起的脑损伤范围,减轻水肿,提高血PGI2/TXA2.以高剂量效果显著且明显降低脑组织中MDA,提高ATP.低剂量可明显降低血浆NO,增加ET.结论阿司匹林对脑缺血-再灌损伤有明显保护作用,其机制可能与提高PGI2/TXA2、减少氧自由基和提高ATP含量有关.
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