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Effects of cyclosporin A aerosol on airway hyperresponsiveness in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.2003.07.005
- Key Word:
- 气道高反应性;气道阻力;肺动态顺应性;氯化乙酰甲胆碱;环孢素A
Abstract： 目的评价环孢素A气雾吸入给药对致敏大鼠气道高反应性的影响.方法用氯化乙酰甲胆碱(Mch)诱导抗原攻击后的致敏大鼠气道阻力(Raw)、肺动态顺应性(Cdyn)、PC50和PC25变化,观察环孢素A气雾吸入给药后的抗气道高反应性作用.结果环孢素A 5,20 g*L-1气雾吸入给药,色甘酸钠20 g*L-1气雾吸入给药和地塞米松 (0.5 mg*kg-1, ip) 抑制Mch诱导的大鼠Raw增高及Cdyn降低,增加Raw PC50和 Cdyn PC25值.结论环孢素A气雾吸入给药能预防Mch引起的大鼠气道高反应性,是其治疗哮喘的一个有效途径.
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