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Inhibition of magnesium lithospermate B on the c-Jun N-terminal kinase 3 mRNA expression in cardiomyocytes encountered ischemia/reperfusion injury

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
7
DOI:
10.3321/j.issn:0513-4870.2003.07.004
Key Word:
c-Jun N-末端激酶3;心肌细胞;缺血/再灌注;紫草酸镁B

Abstract: 目的探讨c-Jun N-末端激酶3(c-Jun N-terminal kinase 3, JNK3)在缺血/再灌注心肌细胞损伤中的作用,及紫草酸镁B对缺血/再灌注心脏具有保护作用的机制.方法复制大鼠Langendorff心肌缺血/再灌注损伤模型, 用原位杂交技术检测心肌细胞JNK3 mRNA的表达,并观察紫草酸镁B对JNK3表达的影响.结果图像分析显示,心肌缺血30 min/再灌注30 min时,JNK3表达明显高于非灌注组和对照组.0.1,1和10 μmol*L-1紫草酸镁B可以抑制缺血/再灌注时JNK3 mRNA的表达.结论紫草酸镁B可通过抑制JNK3的表达以降低JNK的功能,从而减少心肌细胞凋亡的发生,对缺血/再灌注心脏产生保护作用.

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