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Effects of human recombinant interleukin-1 receptor antagonist on isolated trachea smooth muscle of the guinea pig
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2003.06.003
- Key Word:
- 白细胞介素-1受体拮抗剂;组胺;乙酰胆碱;5-羟色胺;卵白蛋白;气管平滑肌
Abstract： 目的观察人重组白细胞介素-1受体拮抗剂(IL-1ra)对豚鼠离体气管平滑肌(TSM)的影响.方法用离体器官装置、张力换能器、MedLab记录系统测定TSM张力.结果 IL-1ra对正常TSM和卵白蛋白致敏TSM有直接舒张作用,EC50分别为8.06×10-8和5.88×10-7mol*L-1.IL-1ra可剂量依赖性抑制或拮抗His,ACh和5-HT引起的气管收缩.但低浓度却增强ACh收缩作用.IL-1ra亦能显著抑制或对抗卵白蛋白致敏豚鼠的气管收缩,IC50为4.48×10-7 mol*L-1.结论在一定浓度范围内,IL-1ra对正常、痉挛和致敏的豚鼠离体气管平滑肌都有松弛作用.
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