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Effects of potassium channel blockers on the proliferation of rat bronchial smooth muscle cells

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
5
DOI:
10.3321/j.issn:0513-4870.2003.05.004
Key Word:
气道平滑肌细胞;钾通道;4-氨基吡啶;四乙铵;格列苯脲

Abstract: 目的探讨电压依赖性延迟整流钾通道(KV)、Ca2+激活钾通道(KCa)和ATP敏感性钾通道(KATP)对大鼠支气管平滑肌细胞(BSMC)增殖的影响. 方法应用免疫细胞化学、MTT微量比色分析法及流式细胞术,观察KV,KCa和KATP对培养中大鼠BSMC增殖的影响.结果 KV阻断剂4-氨基吡啶(4-AP)显著促进大鼠BSMC增殖细胞核抗原的表达,提高BSMC吸光度值,使S+G2M期细胞数显著增多,并显著提高基础状态下BSMC内Ca2+浓度,而KCa阻断剂四乙铵(TEA)和KATP阻断剂格列本脲(Glib)均无此效应. 结论大鼠BSMC KV活性的抑制,可提高细胞内Ca2+浓度,促进细胞的增殖,而KCa和KATP对BSMC的增殖均无明显影响.

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