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Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2003.04.005
- Key Word:
- 吡酮酸;前药;咪唑;抗菌活性
Abstract： 目的研究含N-乙基-2-甲基-5-硝基咪唑的诺氟沙星、环丙沙星和依诺沙星衍生物的合成及其抗菌活性.方法用含2-甲基-5-硝基咪唑的诺氟沙星、环丙沙星和依诺沙星等为原料,通过亲核取代、酯化合成目的物;测定目的物的抗菌活性.结果设计、合成了9个新化合物(IIa～c,IIIa～f),其结构经MS,1HNMR和元素分析确证.化合物IIa～c的体内抗菌活性较明显.结论化合物IIa～c显示了一定的体内抗菌活性,值得进一步研究.
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