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Potentiation and mechanism of cisplatin-induced apoptosis by lidamycin in human hepatoma BEL-7402 cells

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0513-4870.2003.04.003
Key Word:
力达霉素;顺铂;协同作用;细胞凋亡;肝癌细胞

Abstract: 目的研究抗肿瘤抗生素力达霉素与顺铂的体外协同抗肿瘤作用及其机制.方法采用克隆形成法、流式细胞术、琼脂糖凝胶电泳、Hoechst 33342和PI双荧光染色法、Western blot等方法.结果力达霉素与顺铂联合对人肝癌BEL-7402细胞有很强的协同杀伤作用;可以使BEL-7402细胞的DNA 出现明显的梯状断裂;可以使阻滞于S期的BEL-7402细胞减少而使凋亡细胞比例明显增多;联合用药后BEL-7402细胞核出现明显的凋亡形态变化;使BEL-7402细胞内Bcl-2的表达显著降低.结论力达霉素可以增强顺铂的抗肿瘤作用,提示力达霉素与顺铂联合有望应用于肿瘤联合化疗.

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