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A new vomiting animal model--mink
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2003.02.003
- Key Word:
- 呕吐;水貂;顺铂;昂丹司琼;阿朴吗啡;X射线
Abstract： 目的用水貂建立一种新型呕吐动物模型.方法将水貂随机分组,给予3种经典致呕剂顺铂、阿朴吗啡、硫酸铜及X射线全身照射,测定致吐反应和抗呕吐药的抗呕吐反应,最后取水貂肠管进行5-HT免疫组化检测.结果顺铂(7.5 mg*kg-1,ip)、阿朴吗啡(1.6 mg*kg-1,sc)和硫酸铜(40 mg*kg-1,ig)3种致呕剂均使水貂发生恶心、干呕和呕吐,顺铂引起水貂呕吐的阈值剂量为5 mg*kg-1.昂丹司琼和甲氧氯普胺可抑制顺铂和阿朴吗啡所致的干呕、呕吐.5-HT免疫组化结果提示,肠道EC细胞5-HT释放参与呕吐的发生机制.结论水貂可作为一种新型呕吐模型,这对于抗呕吐机制和新药筛选研究有意义.
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