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Antioxidant effect of Ganoderma polysaccharide peptide
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2003.02.002
- Key Word:
- 四氧嘧啶;灵芝多糖肽;低密度脂蛋白;抗氧化作用
Abstract： 目的研究灵芝多糖肽(GLPP)的抗氧化作用及其机制. 方法 Cu2+诱导人血清低密度脂蛋白(LDL)氧化及iv四氧嘧啶(75 mg*kg-1)引发小鼠氧自由基损伤.结果 GLPP使LDL氧化修饰减少,氧化产物REM降低.GLPP 50,100,200和400 mg*kg-1 ip 20 d,使血清和心肌匀浆的丙二醛(MDA)水平下降, 谷胱甘肽过氧化物酶(GSHpx)升高,超氧化物歧化酶(SOD)减少,过氧化氢酶(CAT)不变.结论 GLPP具有体内外抗氧化作用,其抗氧化作用与清除氧自由基或提高GSHpx水平有关.
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