You Position: Home > Paper
EFFECTS OF GINSENOSIDE Rg1 AND ITS METABOLITE Rh1 ON THE FUNCTION OF IMMUNOCYTE IN MICE
( views:284, downloads:44 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2002.12.004
- Key Word:
- 人参皂苷Rh1;人参皂苷Rg1;免疫细胞
Abstract： 目的初探人参皂苷Rg1及其肠内菌代谢产物Rh1对正常小鼠免疫功能的影响.方法用Rh1与Rg1分别处理脾T细胞,B细胞及腹腔巨噬细胞(Mφ);MTT比色法测T和B细胞增殖能力;中性红比色法测Mφ的吞噬功能;Griess法测Mφ释放NO的水平.结果 Rh1能促进脾细胞增殖、下调Con A诱导的T细胞增殖;Rh1与Rg1对LPS诱导的B细胞增殖均无明显作用;Rg1和Rh1能提高Mφ的吞噬能力和促进NO的释放.结论 Rg1及其代谢产物Rh1可共同作用于T细胞和Mφ而产生免疫调节作用.
- [1]王毅,刘铁汉,王巍,等.人参皂苷Rg1的肠内菌代谢及其代谢产物吸收入血的研究[J].2000,(4).
- [2]王毅,王本祥,刘铁汉,等.人参皂苷Rg1的肠内菌代谢Ⅱ.人参皂苷Rg1和Rh1免疫活性1[J].2000,(9).
- [3]F Y, Liew,F E, Cox.Nonspecific defence mechanism: the role of nitric oxide.[J].1991,12(3).
- [4]三川 潮,Sung Chung Ki,Han Byung Hoon,等.Radioimmunoassay for the Determination of Ginseng Saponin, Ginsenoside Rg_1[J].1982,30(5).
- [5]M, Liu,J T, Zhang.[Immunoregulatory effects of ginsenoside Rg1 in aged rats].[J].1995,30(11).