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EFFECT OF NO ON SECURININE-INDUCED LONG-TERM POTENTIATION IN DENTATE GYRUS OF THE HIPPOCAMPUS OF ANESTHETIZED RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2002.12.002
- Key Word:
- 突触传递长时程增强;一叶(艹秋)碱;一氧化氮;逆行性信使
Abstract： 目的研究一叶(艹秋)碱对麻醉大鼠突触可塑性形成中一氧化氮(nitric oxide,NO)的作用.方法以在体记录突触传递长时程增强(long-term potentiation,LTP)的电生理学方法,记录大鼠海马齿状回颗粒细胞层群峰电位(population spike,PS);以硝酸还原酶法测定NO含量.结果在侧脑室给予0.2 nmol*L-1一叶(艹秋)碱(securinine,5 μL)前给予1 μmol*L-1 7-硝基吲唑可抑制LTP的诱导.给药前ip L-精氨酸250 mg*kg-1可逆转这种抑制作用.取脑进行NO含量测定,与一叶(艹秋)碱对照组相比,7-硝基吲唑+一叶(艹秋)碱给药组的NO含量明显下降.结论选择性一氧化氮合酶(nNOS)抑制剂7-硝基吲唑抑制一叶(艹秋)碱对LTP的诱导;由nNOS催化产生的NO参与了一叶(艹秋)碱诱导LTP的过程.
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