You Position: Home > Paper

ANTIOXIDANT ACTIVITY OF 2-ETHYL-3-HYDROXY-6- PHENYLTHIO-4(1H)-PYRIDONE

( views:144, downloads:0 )
Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
11
DOI:
10.3321/j.issn:0513-4870.2002.11.004
Key Word:
2-乙基-3-羟基6-苯硫基-4(1H)-吡啶酮;电子自旋共振;线粒体膜流动性;自由基

Abstract: 目的研究2-乙基-3-羟基6-苯硫基-4(1H)-吡啶酮(HPP)的抗氧化作用.方法用电子自旋共振(ESR)法测定HPP对羟自由基的清除作用,用荧光法测定大鼠线粒体膜的流动性,用比色法测定给药后小鼠血清中超氧化物歧化酶(SOD)及肝线粒体中谷胱甘肽过氧化物酶(GSH-Px)的活力.结果 HPP对羟自由基有较强的清除作用,显著促进线粒体膜的流动性,明显提高给药小鼠血清中SOD和线粒体中GSH-Px的活力.结论 HPP有显著的抗氧化作用.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn