You Position: Home > Paper
EFFECTS OF NOCISTATIN AND NOCISTATIN (10～17) ON NOCICEPTIN IN ANTAGONIZING ENDOMORPHIN-1 AND ENDOMORPHIN-2 ANALGESIA IN MICE
( views:461, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0513-4870.2002.11.002
- Key Word:
- 固相多肽合成;痛稳素;孤啡肽;内吗啡肽-1;内吗啡肽-2;镇痛
Abstract： 目的研究痛稳素及其碳末端八肽在小鼠脑内对孤啡肽对抗内吗啡肽-1及内吗啡肽-2镇痛作用的影响.方法以固相多肽合成法合成了痛稳素及其碳末端八肽,侧脑室注射孤啡肽、痛稳素及其碳末端八肽,用辐射热甩尾法测定痛阈.结果孤啡肽可对抗内吗啡肽-1及内吗啡肽-2的镇痛作用;痛稳素及其碳末端八肽不影响小鼠的基础痛阈,但可逆转孤啡肽对抗内吗啡肽-1及内吗啡肽-2的镇痛作用.结论痛稳素及其碳末端八肽在脊髓以上水平可逆转孤啡肽对抗内吗啡肽-1及内吗啡肽-2的镇痛作用.
- [1]Dong Shouliang,Wang Tao,Chen Qiang.Synthesis, structure-activity relationship of nociceptin and its fragments[J].1999,44(18).
- [2]Mogil JS,Belknap JK,Grisel JE,etc.Orphanin FQ is a functional anti-opioid peptide.[J].1996,75(2).
- [3]Reinscheid, Rainer K.,Nothacker, Hans-Peter.Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor.[J].1995,270(5237).
- [4]E, Okuda-Ashitaka,T, Minami,S, Tachibana,etc.Nocistatin, a peptide that blocks nociceptin action in pain transmission.[J].1998,392(6673).
- [5]J C, Meunier,C, Mollereau,L, Toll,etc.Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.[J].1995,377(6549).
- [6]Belknap JK,Zhangs G,Mogil JS,etc.Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.[J].1996,214(2).
- [7]Sakashita Y,Yamamoto T.Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test.[J].1999,262(3).
- [8]Crescenzi O.,Picone D.,Tancredi T.,etc.Solution structure of nocistatin, a new peptide analgesic[J].2000,53(3).
- [9]C S, Zhao,B S, Li,G Y, Zhao,etc.Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia.[J].1999,10(2).
- [10]Catherine Mollereau,Marc Parmentier,Pierre Mailleux,etc.ORL1, a novel member of the opioid receptor family: Cloning, functional expression and localization[J].1994,341(1).
- [11]A. Loffet.Improvement to the Esterification Procedure Used in Solid Phase Peptide Synthesis[J].1971,3(1-4).
- [12]J E, Zadina,L, Hackler,L J, Ge,etc.A potent and selective endogenous agonist for the mu-opiate receptor.[J].1997,386(6624).
- [13]Nakagawa T,Kaneko M,Inamura S,etc.Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats.[J].1999,265(1).
- [14]Huo Xiaofeng,Ren Weihua,Wu Ning.Structure - activity relationship of endomorphins and their analogs[J].2001,46(13).
- [15]Yan-Qing Wang,Chong-Bin Zhu,Gen-Cheng Wu,etc.Effects of orphanin FQ on endomorphin-1 induced analgesia[J].1999,835(2).
- [16]L S, Stone,C A, Fairbanks,T M, Laughlin,etc.Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2.[J].1997,8(14).