You Position: Home > Paper
ANTAGONISTIC EFFECT OF CURCUMIN ON SODIUM ARSENITE INDUCED DNA DAMAGE IN MICE
( views:181, downloads:4 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0513-4870.2002.11.001
- Key Word:
- 姜黄素;亚砷酸钠;DNA链断裂
Abstract： 目的观察姜黄素对亚砷酸钠诱发小鼠体内免疫器官细胞DNA链断裂损伤的拮抗作用.方法用单细胞凝胶电泳法.结果亚砷酸钠单独染毒后的DNA链断裂损伤的高峰期各器官不同,脾脏为染毒后1 h,胸腺和骨髓在染毒后3 h.姜黄素拮抗亚砷酸钠引起的各器官DNA链断裂损伤的作用在高峰期明显,表现为彗星细胞百分比降低,并有量效关系.结论姜黄素可以预防亚砷酸钠诱发的小鼠脾脏、胸腺和骨髓细胞的DNA链断裂损伤.
- [1]M T, Huang,W, Ma,P, Yen,etc.Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis.[J].1997,18(1).
- [2]V K, Shalini,L, Srinivas.Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa).[J].1987,77(1).
- [3]K.B. Soni,M. Lahiri,P. Chackradeo,etc.Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity[J].1997,115(2).
- [4]N P, Singh,M T, McCoy,R R, Tice,etc.A simple technique for quantitation of low levels of DNA damage in individual cells.[J].1988,175(1).
- [5]D, Lerda.Sister-chromatid exchange (SCE) among individuals chronically exposed to arsenic in drinking water.[J].1994,312(2).
- [6]Krishna TP,Goud VK,Krishnaswamy K,etc.Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin.[J].1998,30(2).
- [7]K. Indira Priyadarsini,Sujata M. Khopde,M. N. A. Rao,etc.Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue[J].1999,80(2).
- [8]J R, Gurr,Y C, Lin,I C, Ho,etc.Induction of chromatid breaks and tetraploidy in Chinese hamster ovary cells by treatment with sodium arsenite during the G2 phase.[J].1993,319(2).