You Position: Home > Paper
RECOMBINANT HUMAN BRAIN NATRIURETIC PEPTIDE ON THE CARDIAC HEMODYNAMICS AND RENAL FUNCTION IN DOGS WITH HEART FAILURE
( views:169, downloads:24 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2002.10.002
- Key Word:
- 重组人脑钠肽(rhBNP);心衰犬;血流动力学;肾功能
Abstract： 目的研究国产重组人脑钠肽(rhBNP)对慢性心衰犬血流动力学及肾功能的影响.方法用右心室快速起搏(RVP)或狭窄下腔静脉(TIVCC)形成犬的心衰模型.结果 RVP心衰犬iv rhBNP后,平均动脉压(MAP)、左室内压(LVSP)、LVdp/dt、肺动脉压(PAP)、左室舒张末期压(LVEDP)、总外周阻力(TPR)及肾血管阻力(RVR)呈剂量依赖性下降,LVdp/dt/P、左室做功(LVW)、心输出量(CO)和心率(HR)无明显改变;TIVCC心衰犬在iv同剂量rhBNP后,MAP,LVEDP和CO下降,其他心功能指标无明显改变.两种心衰犬给药后尿量和尿钠排出量均增加.结论 rhBNP有舒张血管和利尿作用,能明显降低心衰犬的心脏前后负荷,不影响心脏收缩功能.
- [1]L S, Marcus,D, Hart,M, Packer,etc.Hemodynamic and renal excretory effects of human brain natriuretic peptide infusion in patients with congestive heart failure. A double-blind, placebo-controlled, randomized crossover trial.[J].1996,94(12).
- [2]J G, Lainchbury,J C, Burnett,D, Meyer,etc.Effects of natriuretic peptides on load and myocardial function in normal and heart failure dogs.[J].2000,278(1).
- [3]Roger M. Mills,Thierry H. LeJemtel,Darlene P. Horton,etc.Sustained hemodynamic effects of an infusion of nesiritide (human b-type natriuretic peptide) in heart failure: A randomized, double-blind, placebo-controlled clinical trial[J].1999,34(1).
- [4]P W, Armstrong,T P, Stopps,S E, Ford,etc.Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure.[J].1986,74(5).
- [5]M, Mukoyama,K, Nakao,K, Hosoda,etc.Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.[J].1991,87(4).
- [6]Robert E Hobbs,Leslie W Miller,Corrine Bott-Silverman,etc.Hemodynamic Effects of a Single Intravenous Injection of Synthetic Human Brain Natriuretic Peptide in Patients With Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy[J].1996,78(8).
- [7]Xiongbin Lin,Jorg Hanze,Frauke Heese,etc.Gene Expression of Natriuretic Peptide Receptors in Myocardial Cells[J].1995,77(4).
- [8]Bruce C. Stein,Richard I. Levin.Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease[J].1998,135(5).
- [9]M, Yoshimura,H, Yasue,E, Morita,etc.Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure.[J].1991,84(4).