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EFFECTS OF DONEPEZIL ON THE DELAYED RECTIFIER-LIKE POTASSIUM CURRENT IN PYRAMIDAL NEURONS OF RAT HIPPOCAMPUS AND NEOCORTEX
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2002.06.005
- Key Word:
- donepezil;海马;新皮层;延迟整流钾电流;膜片钳技术
Abstract： 目的探讨donepezil对大鼠海马和新皮层锥体神经元具有延迟整流样特性钾电流(IK)的影响.方法用膜片钳全细胞记录法.结果 Donepezil在微摩尔水平即可抑制IK,并呈剂量依赖性和电压依赖性,且可使IK的稳态激活曲线向超级化的方向移动.结论低浓度donepezil即可抑制大鼠海马和新皮层锥体神经元电压激活的IK,此作用可能与其抑制胆碱酯酶活性协同,参与药物的治疗效应.
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