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SYNERGISTIC ANTITUMOR EFFECT OF SODIUM CAFFEATE AND MITOMYCIN
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2002.06.002
- Key Word:
- 咖啡酸;咖啡酸钠;丝裂霉素;协同作用
Abstract： 目的研究咖啡酸钠(CA-Na)与化疗药物丝裂霉素(MMC)抗肿瘤的协同作用.方法用MTT方法、流式细胞法和Western Blotting方法.结果 CA-Na与MMC合用对BEL-7402细胞增殖的抑制具有协同作用.MMC与CA-Na合并用药后BEL-7402细胞周期的变化与单用MMC不同.合用CA-Na后胞内Ca2+含量明显增加;线粒体膜电位有较大幅度的降低;合用还可协同抑制Bcl-2的蛋白表达、活化caspase-3的表达.CA-Na与MMC合用对移植性小鼠肿瘤的生长有抗肿瘤协同作用. 结论 CA-Na和MMC体内外合用均具有抗肿瘤协同作用.
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