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EFFECT OF PRAERUPTORUM CAUMARIN ON CARDIAC MASS, MYOCARDIAL [Ca2+]i AND Na+, K+-ATPase, Ca2+, Mg2+-ATPase ACTIVITY IN RENOVASCULAR HYPERTENSIVE RATS

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0513-4870.2002.06.001
Key Word:
前胡香豆素;高血压;Na+,K+-ATP酶;Ca2+,Mg2+-ATP酶

Abstract: 目的研究前胡香豆素组分对肾型高血压左室肥厚的预防和逆转作用及机制.方法用两肾一夹肾型高血压左室肥厚大鼠(RHR)模型,测定前胡香豆素组分对其血压、左室湿重、心肌细胞面积、胞内静息钙及胞膜和线粒体ATP酶活性的影响.结果前胡香豆素组分(30 mg*kg-1*d-1,ig)预防组及逆转组大鼠血压、左室湿重/体重均较肥厚组明显降低;左室心肌细胞面积、胞内静息钙均较肥厚组降低;对KCl致钙浓度升高亦明显低于肥厚组;两组均可增加心肌细胞膜及线粒体Na+,K+-ATP酶和Ca2+,Mg2+-ATP酶活性.结论前胡香豆素组分可预防及逆转RHR左室肥厚,减少心肌细胞内钙含量,增加ATP酶活性.

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