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ESTABLISHMENT OF IMMUNE INSULIN RESISTANCE MODEL IN THE RATS BY IV INJECTION OF BCG
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.2002.05.001
- Key Word:
- 卡介苗;胰岛素抵抗;正糖钳;糖尿病
Abstract： 目的建立并考察卡介苗诱导的胰岛素抵抗动物模型.方法用正糖钳实验方法及其他生化检验方法测定卡介苗每鼠10 mg iv后大鼠血糖、葡萄糖耐量、血清TNF-α、胰岛素刺激的葡萄糖代谢速率及其他生化指标的变化.结果卡介苗iv后第2,4及8周,动物的葡萄糖耐量均受到损伤,胰岛素刺激的葡萄糖代谢速率显著下降,血清TNF-α含量升高.结论卡介苗iv可造成稳定的胰岛素抵抗模型,其造模机理可能与升高大鼠血清TNF-α含量有关.
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