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EXPERIMENTAL STUDIES ON THE ANTI-THROMBOSIS EFFECT OF 3,4-OXO-ISOPROPYLIDENE-SHIKIMIC ACID
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2002.04.002
- Key Word:
- 异亚丙基莽草酸;血栓;大脑中动脉;脑缺血;脑梗死;血小板聚集
Abstract： 目的研究异亚丙基莽草酸(ISA)对大鼠动静脉环路血栓、大脑中动脉栓塞及血小板聚集的对抗作用及机制.方法用动静脉环路血栓及三氯化铁致大脑中动脉栓塞(MCAT)模型观察药物作用;并研究了ISA体内、外给药对血小板聚集的影响.结果 ISA 25,50,100及200 mg*kg-1 ig均可显著降低大鼠体外血栓重量;ISA 50,100,200 mg*kg-1 ig可明显改善MCAT模型大鼠神经症状;ISA 100及200 mg*kg-1 ig MCAT模型大鼠脑梗塞范围分别下降27.8%和31.6%;另外,ISA体内、外给药对ADP和胶原诱导的血小板聚集有明显的抑制作用.结论 ISA可能通过抗血小板聚集作用抑制血栓的形成.
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