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PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF PROBUCOL INCLUSION COMPLEX CAPSULE IN HEALTHY DOGS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0513-4870.2002.03.014
- Key Word:
- 普罗布考;药代动力学;相对生物利用度;高效液相色谱法
Abstract： 目的研究普罗布考包合物胶囊在家犬体内的药代动力学与相对生物利用度.方法用高效液相色谱法测定6条健康犬po 250 mg普罗布考片(制剂A)或普罗布考包合物胶囊(制剂B)后不同时间血浆中活性药物的浓度,绘制药-时曲线,计算药代动力学参数及相对生物利用度.结果制剂A和制剂B的药-时曲线符合二室模型,其Tmax均为(9.3±2.1) h,Cmax分别为(1.5±1.0) μg·mL-1和(2.3±0.9) μg·mL-1,AUC0～240分别为(85±56) μg·h·mL-1和(134±55) μg·h·mL-1.以制剂A为参比,制剂B中普罗布考的相对生物利用度为(198±90)%,两种制剂的AUC0～240有显著性差异(P<0.05).结论初步分析认为,改善普罗布考的水溶性是提高普罗布考生物利用度的关键因素之一.
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