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1α,25-DIHYDROXYVITAMIN D3 AND ITS ANALOGUES MODULATE THE PHAGOCYTOSIS OF HUMAN MONOCYTE-DERIVED DENDRITIC CELLS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2002.02.004
- Key Word:
- 骨化三醇;树突状细胞;吞噬功能
Abstract： 目的研究骨化三醇及其类似物他骨化醇和24,25(OH)2D3对单核细胞衍生的树突状细胞(MoDC)的吞噬功能的调节作用.方法以MoDC为研究对象.用流式细胞术分析甘露糖受体(MR)和Fcγ受体的表达,根据细胞摄入酵母多糖的能力评价细胞的吞噬功能.结果骨化三醇和他骨化醇上调MoDC对MR和Fcγ受体的表达,增加MoDC对酵母多糖的摄入使细胞有更强的吞噬功能,但24,25(OH)2D3却无这些调节作用;骨化三醇和他骨化醇的上调作用发生在MoDC分化的早期阶段并且是不可逆的;骨化三醇的作用呈浓度依赖方式.结论骨化三醇及其类似物他骨化醇可能在免疫应答的开始阶段即DC结合和摄取外来抗原的阶段起重要的调节作用.
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