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INHIBITION OF HUMAN LOW-DENSITY LIPOPROTEIN OXIDATION BY SALVIANOLIC ACID-A
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2002.02.001
- Key Word:
- 丹酚酸-A;低密度脂蛋白;抗氧化
Abstract： 目的研究丹酚酸-A(Sal-A)对人血清低密度脂蛋白(LDL)氧化修饰的抑制作用.方法用Cu2+体外诱导LDL过氧化,观察Sal-A对MDA,脂褐素和维生素E含量,氧化LDL电泳迁移率以及对LDL氧化过程中自由基的产生及Sal-A螯合Cu2+的作用.结果LDL经Cu2+诱导过氧化后,丙二醛和脂褐素的生成增加,维生素E含量下降,LDL电泳迁移速度加快,LDL氧化过程中自由基的生成增加.10-6～10-4 mol·L-1 Sal-A可剂量依赖性地抑制上述改变,并且Sal-A能螯合Cu2+.结论丹酚酸-A可有效地抑制Cu2+诱导的人LDL氧化,该作用可能与其清除自由基及螯合铜离子的能力有关.
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