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INHIBITORY EFFECTS OF BENZOISOSELENOTHIAZOLIDONE SULFONAMIDE DERIVATIVES ON CYCLOOXYGENASE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2001.10.004
- Key Word:
- 苯并异硒唑酮磺酰胺衍生物;环氧酶-I;环氧酶-II;环氧酶抑制作用
Abstract： 目的研究苯并异硒唑酮磺酰胺衍生物对环氧酶的抑制作用.方法放免法;RT-PCR法.结果化合物A和B对COX-1和COX-2的代谢产物TXB2和PGE2的IC50比值分别为1 000和560,化合物A和B可抑制LPS诱导的大鼠腹腔巨噬细胞COX-2 mRNA生成,而对COX-1的mRNA生成无影响.结论化合物A和B为COX-2选择性抑制剂,可抑制COX-2 mRNA的生成.
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