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EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF ENDOMORPHIN-1 ON BLOOD PRESSURE IN ANESTHETIZED RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2001.10.003
- Key Word:
- 内吗啡肽-1;降血压作用;阿片受体;中枢M受体
Abstract： 目的观察侧脑室注射内吗啡肽-1(EM-1)对麻醉大鼠血压的影响,并初步探讨其作用机理.方法侧脑室埋植导管给药,颈动脉插管测血压.结果 icv EM-1剂量依赖、纳洛酮敏感地降低麻醉大鼠的血压.iev或iv酚妥拉明、普萘洛尔和iv L-NNA对EM-1引起的血压降低反应无影响;给予阿托品(icv 25 μg@kg-1;或iv 50μg@kg-1)和切断双侧迷走神经减弱EM-1引起的血压降低反应.结论 icy EM-1可引起麻醉大鼠血压降低;此效应由阿片受体介导,有中枢M受体的参与,通过兴奋迷走神经所致.
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