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EFFECTS OF LEFLUNOMIDE ON IMMUNOLOGICAL LIVER INJURY
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2001.10.002
- Key Word:
- 来氟米特;免疫性肝损伤;作用机制
Abstract： 目的研究来氟米特对小鼠免疫性肝损伤的影响.方法利用BCG+LPS诱导免疫性肝损伤;分光光度法检测血中ALT,AST和NO水平及肝匀浆MDA和GSHpx含量;ELISA法测定血中TNF-α含量;细胞增殖法测定IL-1,IL-2及ConA诱导的脾淋巴细胞增殖反应.结果在BCG+LPS诱导的免疫性肝损伤中,来氟米特(4,12,36mg@kg-1)ig给药明显降低免疫性肝损伤小鼠增高的血浆ALT和AST活性及肝匀浆MDA含量,使降低的肝匀浆GSHpx水平增高.进一步研究发现来氟米特明显抑制免疫性肝损伤小鼠TNF-α的产生,降低增高的血清NO水平,抑制PMФ产生过高的IL-1,对低下的IL-2产生和ConA诱导的脾淋巴细胞增殖反应有进一步抑制作用.结论来氟米特对免疫性肝损伤具有保护作用.
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