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EFFECT OF BICYCLOL ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY: ENERGETIC METABOLISM AND MITOCHONDRIAL INJURY IN ACETAMINOPHEN-INTOXICATED MICE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2001.10.001
- Key Word:
- 双环醇;扑热息痛(对乙酰氨基酚);31P磁共振波谱学(31P-MRS);线粒体;能量代谢
Abstract： 目的研究双环醇对扑热息痛(对乙酰氨基酚)引起小鼠肝能量代谢紊乱和线粒体功能障碍的保护作用.方法小鼠ip扑热息痛120 mg@kg-1引起急性肝损伤,观察血清谷丙转氨酶(ALT)和谷草转氨酶(AST)水平、肝活体磷谱、肝线粒体膜流动性及线粒体ATPase活性的改变.结果双环醇可显著抑制扑热息痛中毒小鼠PME/ATP及PME/PDE的升高.双环醇(200 mg@kg-1)可显著降低扑热息痛导致的线粒体膜流动性下降,并对线粒体ATPase活性降低有显著保护作用.结论双环醇可保护扑热息痛导致的急性肝损伤,使肝脏能量代谢和磷脂代谢趋于正常,并对损伤的线粒体功能有显著的保护作用.
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