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ANTIFIBROTIC EFFECTS OF GENISTEIN AND QUERCETIN IN VITRO
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2001.09.003
- Key Word:
- 染料木素;槲皮素;抗纤维化作用
Abstract： 目的研究染料木素和槲皮素对体外肝维化的保护作用.方法细胞增殖和胶原合成分别用结晶紫染色法和3H-脯氨酸参入法.原胶原mRNA水平用RT -PCR法测定.结果染料木素(25-70 μmol*L-1)和槲皮素(6.25-50 μmol*L-1)浓度依赖抑制PDGF促HSC-T6细胞增殖和TGFβ1刺激的胶原合成及I型原胶原mRNA的表达.结论染料木素和槲皮素抑制PDGF和TGFβ1对星状细胞的作用可能对肝纤维化有保护作用.
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