You Position: Home > Paper

INHIBITORY EFFECTS OF ISORHAPOTIGENIN ON IL-8 PRODUCTION AND mRNA EXPRESSION INDUCED WITH TNFα IN NORMAL HUMAN SYNOVIAL CELLS

( views:168, downloads:12 )
Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0513-4870.2001.06.002
Key Word:
异丹叶大黄素;白细胞介素-8;放免测定法;反转录聚合酶链式反应

Abstract: 目的研究异丹叶大黄素(isorhapotigenin,Iso)对肿瘤坏死因子α(TNF-α)诱导的人滑膜细胞(human synovial cell, HSC)白细胞介素-8(IL-8)生成和mRNA表达的影响.方法用RIA方法测定IL-8的含量,以RT-PCR法测IL-8 mRNA.结果 Iso在1×10-6-1×10-5 mol*L-1浓度范围内对TNF-α诱导的人滑膜细胞IL-8生成有抑制作用,并抑制TNF-α诱导的HSC IL-8 mRNA表达.结论 Iso抑制TNF-α诱导的HSC IL-8生成,可能与影响IL-8 mRNA表达有关.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn