EFFECT OF STILBENE POLYMER (Gn-3) ON EXPERIMENTAL LIVER INJURIES IN MICE
- Author:
- No author available
- Journal Title:
- Acta Pharmaceutica Sinica
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2001.02.001
- Key Word:
- 肝损伤;二苯乙烯低聚体;白三烯受体拮抗剂
Abstract： AIM To study the protective effect of Gn-3 (a stilbene polymer isolated from Gnetum parvifolium) against liver injury induced by CCl4, N-acetyl-p-aminophenol (APAP) and Bacillus Calmette-Guerin (BCG) plus bacterial lipopolysaccharide (LPS) in mice. METHODS The experimental model of liver injury were induced by 0.1% CCl4 ip (10 mL*kg-1*d-1 for 3d), APAP ip (150 mg*kg-1) or BCG (5 mg) plus LPS (7.5 μg) in mice. The levels of ALT in serum, MDA and GSH in liver tissues were detected. The histopathologic changes were observed by light microscope. RESULTS Gn-3 was shown to markedly reduce the elevated serum ALT levels, liver tissue MDA and improve the histopathological changes in all the three experimental liver injury models. No effect of Gn-3 was observed on the liver GSH level in liver injury mice. CONCLUSION Gn-3 was found to inhibit the development of liver injury caused by CCl4, APAP, or BCG plus LPS. This means that Gn-3 has liver protective effects.
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