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EFFECTS OF BAICALIN ON LIVER MICROSOMAL CYTOCHROME P450 SYSTEM

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
12
DOI:
10.3321/j.issn:0513-4870.2000.12.003
Key Word:
黄芩苷;细胞色素P450;药酶诱导

Abstract: 目的观察黄芩苷对小鼠肝细胞色素P450及其亚家族的影响.方法用紫外分光光度法分别测定小鼠肝微粒体细胞色素P450与b5含量及氨基比林N-脱甲基酶(ADM)、7-乙氧基香豆素O-脱乙基酶(ECD)、苯并芘羟化酶(AHH)活性.用蛋白印迹杂交技术鉴定细胞色素P450同功酶.结果黄芩苷可使小鼠肝微粒体细胞色素P450含量显著增加,并使ADM,ECD及AHH 3种酶活力显著增强.对6种P450同功酶的鉴定结果显示,黄芩苷可选择性诱导1A1,2B1及2C11 3种同功酶,对细胞色素b5含量及3A2,2D1和2E1 3种同功酶无诱导作用.结论黄芩苷对小鼠肝细胞色素P450有选择性诱导作用.

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