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ONE-POT SYNTHESIS OF dl-NAPROXEN BY REARRANGEMENT
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0513-4870.2000.11.005
- Key Word:
- 萘普生;重排;卤化铜;一锅法
Abstract： 目的 "一锅"重排法合成非甾体消炎镇痛药外消旋萘普生.方法以卤化铜为选择性卤化剂,6-甲氧基-2-丙酰基萘经羰基α-卤化、缩酮化、重排和水解等反应合成外消旋体萘普生.结果 "一锅法"合成萘普生总收率74.0%～92.6%(以6-甲氧基-2-丙酰基萘计).结论 "一锅重排法"合成萘普生,操作简便,收率较高.
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