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THE EFFECT OF MELATONIN ON ENHANCING IMMUNE FUNCTION AND INHIBITING THE ABILITY OF NO OVER-RELEASE IN MORPHINE DEPENDENT MICE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0513-4870.2000.11.002
- Key Word:
- 褪黑素;吗啡依赖;免疫功能;一氧化氮
Abstract： 目的探讨褪黑素(MT)对吗啡依赖小鼠免疫功能的影响及其与一氧化氮(NO)的关系.方法 sc吗啡建立小鼠身体依赖模型;纳洛酮催瘾;称量免疫器官重量;Con A刺激的脾细胞淋巴增殖反应;碳粒廓清实验检测小鼠血中单核巨噬细胞的吞噬功能;小鼠腹腔巨噬细胞诱生NO含量的测定.结果 MT可对抗吗啡引起的免疫抑制, 包括阻止吗啡对淋巴细胞增殖反应的抑制;明显提高吗啡依赖小鼠巨噬细胞的吞噬指数;抑制吗啡引起的腹腔巨噬细胞过量释放NO.MT对巨噬细胞的吞噬功能的增强作用可被纳洛酮阻断.结论 MT可提高吗啡依赖小鼠的免疫功能并抑制腹腔巨噬细胞中NO的过量释放.
- [1]Y, Qiu,L, Kang,X, Qiu.[The inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice].[J].1998,78(9).
- [2]X Q, Wei,I G, Charles,A, Smith,etc.Altered immune responses in mice lacking inducible nitric oxide synthase.[J].1995,375(6530).
- [3]应水旺,张家驹.褪黑激素对脑机能的影响[J].1987,(3).
- [4]K, Fecho,K A, Maslonek,L A, Dykstra,etc.Mechanisms whereby macrophage-derived nitric oxide is involved in morphine-induced suppression of splenic lymphocyte proliferation.[J].1995,272.
- [5]Andrew W. Taylor-Robinson,Foo Y. Liew,Alison Severn,etc.Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells[J].1994,24(4).
- [6]许建明.褪黑素抑制一氧化氮生成在小鼠免疫性肝损伤中的意义[J].1998,(6).