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PHARMACOKINETICS AND DISPOSITION OF β-ELEMENE IN RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2000.10.002
- Key Word:
- β-榄香烯;气相色谱法;药代动力学
Abstract： 目的研究β-榄香烯在大鼠体内的药代动力学及其体内过程.方法用GC法测定生物样品中β-榄香烯浓度.结果大鼠iv β-榄香烯50,75,100 mg·kg-1的时量曲线属二室模型,药物自血浆消除较快,且呈线性动力学.大鼠ip本品100 mg·kg-1的时量曲线属一室模型,但其消除慢于iv.本品自大鼠尿、粪、胆汁的排出量均很少.β-榄香烯的平均血浆蛋白结合率为97.7%.结论β-榄香烯在大鼠体内吸收快、分布广、消除快、蛋白结合率高,经尿、粪、胆汁排泄不是本品的主要消除途径.
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