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SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTITUMOR ACTIVITY OF DIORGANOTIN(IV) COMPOUNDS OF 4-ACYL-5-PYRAZOLONE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2000.09.005
- Key Word:
- 二烃基锡化合物;4-酰基-5-吡唑酮;抗癌活性
Abstract： 目的设计合成一系列新型有机锡化合物,通过药理筛选寻找具有抗肿瘤活性的药物并探讨其构效关系.方法以4-酰基-5-吡唑酮为配体合成有机锡化合物,用元素分析、红外光谱、 1H,13C,119Sn NMR等方法对得到的化合物作结构表征并利用几种药理模型进行体外抗癌活性筛选.结果合成了一系列R2SnL2 型有机锡新配合物并确定其结构.结论药理筛选结果表明,多个化合物(3～6,9～11)对HL-60, HCT-8, Bel-7402,BGC-823和KB癌细胞有效,显示了较强的抗癌活性.
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