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EFFECTS OF DL111-IT ON DECIDUA, PGs CONTENTS AND UTERINE CONTRACTILITY IN PREGNANT RATS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2000.09.001
- Key Word:
- 抗孕唑;前列腺素;子宫蜕膜;子宫收缩
Abstract： 目的研究抗孕唑对妊娠大鼠子宫蜕膜组织形态,PGF2α和PGE2含量及对离体大鼠子宫收缩幅度的影响.方法用HE染色,放射免疫法和离体子宫收缩记录等方法.结果抗孕唑使妊娠大鼠子宫蜕膜细胞受损、剥离,并使子宫和血清中PGE2和PGF2α的含量升高; 对离体妊娠大鼠子宫有收缩作用,其效价为米索前列醇的0.6倍.结论抗孕唑损伤蜕膜细胞,刺激释放前列腺素,并可提高早孕子宫对催产素和米索前列醇的敏感性.
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