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m-CHLOROPHENYLPIPERAZINE-INDUCED ANXIETY MODEL IN LIGHT-DARK BOX IN DDY MICEA NEW ECONOMIC AND SIMPLE METHOD FOR SCREENING ANXIOLYTICS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0513-4870.2000.08.005
- Key Word:
- 间氯苯哌嗪;地西泮;焦虑模型;ddy小鼠;ICR小鼠
Abstract： 目的建立经济简便的抗焦虑药模型.方法用间氯苯哌嗪(mCPP)诱导产生焦虑,观察ddy小鼠和ICR小鼠在明暗箱的行为表现.结果 mCPP在sc 1～4 mg·kg-1的剂量下即可显著降低ddy小鼠在明箱的活动次数,而对暗箱的活动次数影响不显著;mCPP在sc 2～10 mg·kg-1的剂量下对ICR小鼠在明箱的的活动次数影响不明显;用地西泮对该模型进行验证,发现只用较小的样本量即可得出显著结果.结论 ddy小鼠可取代Wistar大鼠进行mCPP诱导焦虑的明暗箱模型,且简便易得,经济有效.
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