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EFFECT OF GINSENOSIDE Rb1 ON MOUSE SEXUAL FUNCTION AND ITS MECHANISM
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.2000.07.004
- Key Word:
- 人参皂苷;性功能;海绵体;一氧化氮;环鸟苷酸
Abstract： 目的研究人参皂苷Rb1对小鼠性功能的影响及其作用机制.方法小鼠ip Rb1,每天进行性行为检测, 3周后,测定小鼠血清睾酮浓度、阴茎海绵体组织(MCC)cGMP及NO水平;离体温孵破坏内皮组织的兔海绵体组织(RCC),检测在NO供体硝普钠(SNP)存在下,Rb1对RCC中cGMP水平的影响.结果 Rb1 5.0,10.0 mg.kg-1给药后d 14及d 16,小鼠跨骑和交配次数显著增加,血清睾酮浓度、MCC中cGMP及NO水平提高;Rb1 0.05,0.50, 5.00 μmol.L-1可明显提高离体RCC cGMP浓度.结论 Rb1可显著改善小鼠性功能,其作用机制可能通过提高雄激素水平、激活NO/cGMP通路而起作用.
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