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HYDROCORTISONE INDUCED DECREASE OF LEARNING AND MEMORY FUNCTIONS IN RATS AND ITS RELATED TO OXYGEN FREE RADICAL
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2000.06.005
- Key Word:
- 氢化可的松;脑细胞;学习记忆;氧自由基;超氧化物歧化酶
Abstract： 目的研究氢化可的松(HC)对大鼠学习记忆功能的影响及与氧自由基的关系.方法迷宫法检测实验大鼠的学习记忆功能;Lowry法及硫代巴比妥酸法分别测定胞浆及线粒体的蛋白质及MDA含量;分光光度法及荧光分光光度法分别测定胞浆及线粒体的GSH及GSSG的含量;黄嘌呤氧化酶法及紫外分光光度法分别测定胞浆及线粒体的Mn-SOD及CAT的含量.结果 HC可引起老龄前期大鼠记忆障碍,同时使脑细胞浆与线粒体产生MDA及GSSG增加、GSH及GSH/GSSG比值下降以及Mn-SOD及CAT活性降低.结论 HC同步抑制老龄前期大鼠学习记忆功能是与其降低机体的抗氧化能力和增加氧自由基的损伤有关.
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