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COMPARISON OF PHARMACOKINETICS OF SINGLE-AND MULTIPLE-DOSE OF GLYCODIDAZOLUM NATRIUM(CMNa) IN TUMOR PATIENTS

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0513-4870.2000.06.001
Key Word:
肿瘤放疗增敏药;甘氨双唑钠;药代动力学;高效液相色谱

Abstract: 目的研究甘氨双唑钠(CMNa)的单剂量和多剂量药代动力学,以对CMNa的蓄积性作一评价.方法 5名肿瘤病人, 连续9次, 静脉滴注剂量为700 mg/m2的CMNa静滴液,用HPLC-二极管阵列紫外法测定受试病人全血CMNa浓度, 并用开放型二室模型拟合CMNa的血药浓度-时间曲线.结果 CMNa在病人体内分布及消除都很快, 单剂量和多剂量静滴CMNa后血药浓度值和各药代动力学参数值非常相近,没有明显差别.结论甘氨双唑钠在肿瘤病人体内不蓄积,是一个较安全的放疗增敏药物.

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