You Position: Home > Paper
EFFECT OF ASPIRIN ON TNFα INDUCED ADHESION OF ENDOTHELIAL-NEUTROPHIL AND ENDOTHELIAL-MONOCYTE
( views:235, downloads:16 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.2000.05.001
- Key Word:
- 阿司匹林;内皮细胞;中性粒细胞;单核细胞
Abstract： 目的研究阿司匹林对TNFα诱导的内皮细胞与中性粒细胞及单核细胞粘附的抑制作用及作用机制.方法用髓过氧化酶法测定白细胞与内皮细胞的粘附,ELISA法测定内皮细胞粘附分子的表达.结果阿司匹林(600～900 mg·L-1)可抑制中性粒细胞及单核细胞与TNFα激活6 h的内皮细胞粘附;而TNFα激活内皮细胞后24 h,阿司匹林对单核细胞与其粘附的抑制作用增强但却不抑制中性粒细胞与其粘附.结论阿司匹林通过抑制E-selectin的表达而降低TNFα诱导的内皮细胞与中性粒细胞的粘附,并通过抑制VCAM-1的表达降低TNFα诱导的内皮细胞与单核细胞的粘附.
- [1]D.G. Hassall,P.M.W. Bath,A-M. Gladwin,etc.CD11/CD18 cell surface adhesion glycoproteins: Discordance of monocyte function and expression in response to stimulation[J].1991,196(2).
- [2]E C, Butcher.Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.[J].1991,67(6).
- [3]R, Kacimi,J S, Karliner,F, Koudssi,etc.Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia.[J].1998,82.
- [4]M J, Palmoski,K D, Brandt.Correction of data on salicylate and indomethacin concentrations in cartilage.[J].1985,28.
- [5]林勇,汪钟.白细胞与内皮细胞的粘附[J].1998,(5).
- [6]T A, Springer.Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.[J].1995,57.