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EFFECTS OF 2-(3-ESTRONE-n-ETHYL-PIPERAZINE-METHYL) TETRACYCLINE ON THE LEVELS OF C-FOS AND C-JUN mRNAs AND THEIR PRODUCT PROTEINS IN EPIPHYSEAL PLATE

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0513-4870.2000.04.003
Key Word:
四环素-哌嗪雌酚酮;雌酚酮;原位杂交;免疫组织化学

Abstract: 目的:研究四环素-哌嗪雌酚酮(XW630)对软骨细胞c-fos和c-jun基因的mRNA及其表达产物水平的影响,初步探讨其对骨的作用机制.方法:用原位杂交法,测定体外培养小鼠胚胎长骨骺板c-fos和c-jun mRNA的水平,同时用免疫组织化学法,测定了相应的表达产物.结果:10-7 mol.L-1 XW630可显著上调骺板静止区、增殖区和肥大区c-fos和c-jun的mRNA及其表达产物水平,且其作用比雌酚酮强.结论:XW630可能通过上调软骨细胞c-fos, c-jun的表达,促进软骨细胞中含有AP-1位点的、与骨生长发育有关的基因表达,从而促进软骨内骨形成.

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