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PROTECTIVE ACTION OF PIPEROETHYL ACETYL AMINE AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2000.04.001
- Key Word:
- 乙酰胡椒乙胺;扑热息痛;肝损伤;谷胱甘肽;肝细胞色素P-450
Abstract： 目的:研究乙酰胡椒乙胺(piperoethyl acetyl amine,PAA)对扑热息痛(acetaminophen,AP)肝脏毒性的保护作用及其机制.方法:小鼠ig PAA后ip AP,检测小鼠肝脏的损害程度,高效液相法检测血中AP含量,检测小鼠肝细胞色素P-450含量.结果:PAA明显降低AP所致的小鼠血清转氨酶升高,减轻肝脏病理损害,阻止肝内谷胱甘肽下降,增加肝细胞色素P-450含量,血中AP浓度明显降低.结论:PAA对AP中毒小鼠有明显肝保护作用.
- [1]O H, LOWRY,N J, ROSEBROUGH,A L, FARR,etc.Protein measurement with the Folin phenol reagent.[J].1951,193.