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EFFECTS OF BENZYLENZYLTETRAHYDROPALMATINE(BTHP) ON POTASSIUM CURRENTS AND CALCIUM, SODIUM CURRENTS IN GUINEA PIG VENTRICULAR MYOCYTES

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
2
DOI:
10.3321/j.issn:0513-4870.2000.02.002
Key Word:
苄基四氢巴马汀;心肌细胞;钾电流;膜片钳

Abstract: 目的:研究苄基四氢巴马汀(BTHP)对心肌细胞的作用特点,以探讨其抗心律失常机制.方法:用全细胞膜片钳技术考察BTHP对心室肌细胞钾电流及钙、钠电流的作用.结果:BTHP30μmol·L-1明显阻滞延迟整流钾电流(IK包括:Ikr及Iks).可使Ikr及Ikr,tail的幅值下降,且对Ikr阻滞作用呈频率依赖性;对Iks及Iks,tail幅值也有明显的抑制作用.BTHP200μmol·L-1可明显阻滞Ica,L,使其电流幅值降低,但对IK1,Ica,T,Ina电流均无影响.结论:BTHP可明显阻滞心室肌细胞Ikr,Iks,Ica,L电流,且对Ikr阻滞作用呈频率依赖性.

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