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EFFECTS OF SULFUR COMPOUNDS FROM CAUCAS (ALLIUM VICTORIALIS L.) ON THE SPONTANEOUS BEATING OF MYOCARDIAL CELL SHEETS IN VITRO
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0513-4870.2000.01.002
- Key Word:
- 培养心肌细胞;自发性心率;正性肌力作用;葱;含硫化合物
Abstract： 目的:考察葱(Allium victorialis L.)中的5种化合物对小鼠培养心肌细胞的作用. 方法:制备小鼠的培养心肌细胞,利用微机控制的图像分析监视系统,考察葱中分离出的5种挥发性成分对培养心肌细胞的心率及振幅的作用. 结果:其中二甲基二硫、甲基烯丙基三硫、甲基烯丙基硫醚和二烯丙基二硫对培养心肌细胞的心率和振幅均有明显的增强作用,并对Ca2+-ATP酶有明显的抑制作用,而不含硫的2-戊酮对心率、振幅、Na+,K+-ATP酶及Ca2+-ATP酶均无影响. 结论:含硫化合物引起的正性肌力作用可能与它的酶抑制作用有关.
- [1]B K, Chamberlain,D O, Levitsky,S, Fleischer.Isolation and characterization of canine cardiac sarcoplasmic reticulum with improved Ca2+ transport properties.[J].1983,258.
- [2]P, Ottolenghi.The reversible delipidation of a solubilized sodium-plus-potassium ion-dependent adenosine triphosphatase from the salt gland of the spiny dogfish.[J].1975,151(1).
- [3]L R, Jones,H R, Besch,J W, Fleming,etc.Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities.[J].1979,254.
- [4]Kakiuchi Nobuko,Senaratne Lakshmi,Huang Sheng-Lun,etc.Effects of Constituents of Beli (Aegle marmelos) on Spontaneous Beating and Calcium-Paradox of Myocardial Cells 1[J].1991.
- [5]S L, Huang,N, Kakiuchi,M, Hattori,etc.A new monitoring system of cultured myocardial cell motion: effect of pilose antler extract and cardioactive agents on spontaneous beating of myocardial cell sheets.[J].1991,39(2).
- [6]V, Shoshan,D H, MacLennan.Quercetin interaction with the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum.[J].1981,256.
- [7]I S, Polinger.Separation of cell types in embryonic heart cell cultures.[J].1970,63(1).