You Position: Home > Paper
EFFECT OF OXYPHENAMONE ON CA2+ AFFNITY OF CARDIAC TROPONIN C
( views:100, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.1999.09.005
- Key Word:
- 羟苯氨酮;心肌肌钙蛋白C;钙增敏剂;磺甲唑
Abstract： 目的:探讨羟苯氨酮(oxyphenamone, Oxy)的钙增敏机理.方法:从牛心肌组织中提取cTn C,采用荧光探针标记法观察Oxy对cTn C与Ca2+亲和力的影响,并和已知的钙增敏剂MCI-154、磺甲唑(sulmazole, Sul)作比较.结果:Oxy显著增加cTn C和Ca2+的亲和力,且呈剂量与效应相关.而50 μmol·L-1 MCI-154或Sul对cTn C和Ca2+亲和力曲线均无显著影响.结论:Oxy的钙增敏机理可能与直接增加cTn C与Ca2+的亲和力有关.
- [1]J D, Johnson,J H, Collins,S P, Robertson,etc.A fluorescent probe study of Ca2+ binding to the Ca2+-specific sites of cardiac troponin and troponin C.[J].1980,255.
- [2]Heimo Haikala,Juha Kaivola,Erkki Nissinen,etc.Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan[J].1995,27(9).
- [3]Mabuchi Y,Gergely J,Grabarek Z.Properties of Troponin C Acetylated at Lysine Residues[J].1995,34(37).
- [4]Jolanta Szynkiewicz,Dariusz Stȩpkowski,Hanna Brzeska,etc.Cardiac troponin-C: a rapid and effective method of purification[J].1985,181(2).