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ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM IN UNTREATED ESSENTIAL HYPERTENSION AND RESPONSE TO ANGIOTENSIN CONVERTING ENZYME INHIBITORS
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.1999.09.004
- Key Word:
- 血管紧张素转换酶;基因多态性;原发性高血压;血管紧张素转换酶抑制剂
Abstract： 目的:从基因多态性研究药效的差异.方法:选择健康志愿者99例,未治疗的原发性高血压病人40例,用PCR方法检测血管紧张素转换酶(ACE)基因的插入与缺失(I/D)多态性, 用血管紧张素转换酶抑制剂(ACEI)卡托普利治疗高血压病人.结果:正常人与原发性高血压患者的ACE等位基因频率及基因型频率无显著差异(P>0.05).卡托普利降压有效病人与无效病人ACE基因的I/D等位基因频率及基因型频率,基因缺失型纯合子(DD)或/和杂合子(ID)与非缺失型(II)也均无显著差异(P>0.05).结论:ACE基因的I/D多态性与原发性高血压的发病无关,ACEI降压作用的个体差异与ACE基因的I/D多态性无关.
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