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PHARMACOLOGICAL ACTIONS AND CHRONIC VASCULAR EFFECTS OF Nω-NITRO-L-ARGININE METHYL ESTER, AN INHIBITOR OF NITRIC OXIDE SYNTHASE
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.1999.09.002
- Key Word:
- 一氧化氮合酶抑制剂(L-NAME);一氧化氮;内皮依赖性收缩因子;慢性血管效应
Abstract： 目的:探讨Nω-硝基L-精氨酸甲酯(L-NAME)对不同动脉的慢性血管效应及其与抑制内皮依赖性一氧化氮(EDNO)合成的关系.方法:采用大鼠离体动脉环的张力测定,一氧化氮合酶活性测定及组织学、生化学等方法.结果:给药8周后大鼠尾动脉压明显升高、体重及胸主动脉的内皮依赖性舒张功能明显下降并释放内皮依赖性收缩因子,肠系膜微动脉的内皮依赖性舒张功能无改变.给药8周后出现了动脉中膜肥厚及其周围纤维化.Nω-硝基D-精氨酸甲酯(D-NAME)的慢性给药亦可引起与L-NAME同样的动脉周围纤维化.结论:L-NAME对大鼠胸主动脉及肠系膜微动脉的作用不同,其慢性血管效应与抑制EDNO合成以外的其它机制相关.
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