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REGULATION OF 17β-ESTRADIOL IN HUMAN OSTEOBLAST-LIKE CELL LINES TE85 AND U2

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
9
DOI:
10.3321/j.issn:0513-4870.1999.09.001
Key Word:
17β-雌二醇;骨质疏松;成骨细胞;细胞因子;一氧化氮合酶

Abstract: 目的:以人的类成骨细胞株TE85和U2为细胞模型,观察雌激素对细胞功能的影响.方法:3H-胸腺嘧啶参入法测细胞增殖;ELISA法测细胞因子IL-6含量;精氨酸转化法测iNOS活性.结果:IL-1(20 U·mL-1)和TNFα(50 U·mL-1)刺激细胞分泌IL-6,并抑制细胞增殖.在TE85细胞,17β-雌二醇(E2)可抑制IL-6分泌并能对抗IL-1和TNFα对细胞增殖的影响.NOS抑制剂L-NMMA使细胞3H-胸腺嘧啶的参入降低,E2(1 nmol·L-1)可对抗L-NMMA的抑制作用.结论:E2通过减少IL-6分泌和影响iNOS活性而调节细胞功能.

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