You Position: Home > Paper
MECHANISM OF ANTIARRHYTHMIC EFFECT OF THE ANTIMALARIAL ARTEMISININ
( views:214, downloads:28 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0513-4870.1999.08.003
- Key Word:
- 青蒿素;钾通道;心律失常;内向整流钾通道(Kir 2.1);非洲蛙卵母细胞
Abstract： 目的:探讨青蒿素抗心律失常的离子电流基础.方法:用全细胞膜片钳技术和双电极电压钳技术.结果:当细胞超极化到-100 mV时,青蒿素以浓度依赖方式明显抑制家兔心室肌细胞Ik1, 50 μmol.L-1青蒿素可使家兔心室肌细胞Ik1从对照组的-2.36±0.39 nA减少到-1.43±0.31 nA.给予非洲蛙卵母细胞注射Kir 2.1 cRNA后,用不同浓度青蒿素灌注,可减低Kir 2.1钾通道电流,此作用呈电压和浓度依赖性.青蒿素对Kir 2.1钾通道的阻断作用呈可逆性.结论:青蒿素能有效抑制离体心肌细胞Ik1,其抗心律失常作用机理与其抑制心肌细胞Ik1及阻断Kir 2.1通道电流有关.
- [1]Shimoni Y,Clark R B,Giles W R.Role of an inwardly rectifying potassium current in rabbit ventricular action potential.[J].1992,448(1).
- [2]C A, Doupnik,N, Davidson,H A, Lester.The inward rectifier potassium channel family.[J].1995,5(3).
- [3]I R, Josephson,A M, Brown.Inwardly rectifying single-channel and whole cell K+ currents in rat ventricular myocytes.[J].1986,94.
- [4]Kubo, Yoshihiro,Baldwin, Timothy J..Primary structure and functional expression of a mouse inward rectifier potassium channel.[J].1993,362(6416).
- [5]N, Takahashi,K, Morishige,A, Jahangir,etc.Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.[J].1994,269.
- [6]Yang BF,Luo DL,Bao LH,etc.Artemisinin blocks activating and slowly activating K+ current in guinea pig ventricular myocytes.[J].1998,(3).